Bulger K, Murphy J, Janckila A, Nichols J, McCaffrey R
Section of Medical Oncology, Evans Memorial Department of Clinical Research, Boston University Medical Center, MA 02118.
Leuk Res. 1994 Feb;18(2):101-4. doi: 10.1016/0145-2126(94)90125-2.
Purified leukemia cells from three patients with hairy cell leukemia were studied for IL-2 receptor status. All samples expressed the p55IL-2 receptor subunit. However, none demonstrated sensitivity to the IL-2-diphtheria toxin conjugate, DAB486IL-2, which shows selective cytotoxicity for high affinity IL-2 receptor-bearing cells. In the one case studied with 125I-IL-2 binding, only low affinity IL-2 receptors were noted. These data suggest that hairy cell leukemia cells express only low affinity IL-2 receptors and are insensitive to DAB486IL-2.
对三名毛细胞白血病患者的纯化白血病细胞进行了白细胞介素-2（IL-2）受体状态研究。所有样本均表达p55IL-2受体亚基。然而，无一样本显示对IL-2-白喉毒素偶联物DAB486IL-2敏感，该偶联物对表达高亲和力IL-2受体的细胞具有选择性细胞毒性。在用125I-IL-2结合法研究的一例中，仅发现低亲和力IL-2受体。这些数据表明，毛细胞白血病细胞仅表达低亲和力IL-2受体，且对DAB486IL-2不敏感。
