DeSanto N G, Calò L, Anastasio P, Coppola S, Cantaro S, Favaro S, Capasso G, Borsatti A
Chair of Nephrology, University of Naples, Italy.
Nephron. 1994;66(1):45-51. doi: 10.1159/000187764.
The study was devised to establish the role of prostaglandin E2, prostaglandin1 alpha and thromboxane A2 in the genesis of glomerular hyperfiltration response to a meat meal in healthy humans. To this end, a group of 8 healthy women was studied 4 times: in the control state (study 1), after a meat meal (study 2), following a meat meal associated with intravenous aspirin (study 3) and finally after a meat meal associated with intravenous aspirin following 2-day pretreatment with oral aspirin (study 4). Urinary excretion of prostaglandins and thromboxane increased during the glomerular hyperfiltration response to a meat meal and was suppressed by aspirin administration which did not suppress the renal hemodynamic response to the meat meal. The data do not support a causal role for prostaglandins and thromboxane A2 in the hemodynamic response to acute protein loading.
该研究旨在确定前列腺素E2、前列腺素1α和血栓素A2在健康人对肉类餐后肾小球高滤过反应发生过程中的作用。为此，对一组8名健康女性进行了4次研究：处于对照状态（研究1）、进食肉类餐后（研究2）、进食肉类餐并静脉注射阿司匹林后（研究3），最后在口服阿司匹林预处理2天后进食肉类餐并静脉注射阿司匹林（研究4）。在对肉类餐的肾小球高滤过反应期间，前列腺素和血栓素的尿排泄增加，且阿司匹林给药可抑制其增加，但阿司匹林并未抑制对肉类餐的肾血流动力学反应。这些数据不支持前列腺素和血栓素A2在急性蛋白质负荷的血流动力学反应中起因果作用。
