降解的ι-卡拉胶导致恒河猴结肠黏膜下巨噬细胞溶酶体功能障碍。

Lysosomal dysfunction in colonic submucosal macrophages of rhesus monkeys caused by degraded iota carrageenan.

作者信息

Mankes R, Abraham R

出版信息

Proc Soc Exp Biol Med. 1975 Oct;150(1):166-70. doi: 10.3181/00379727-150-38996.

Abstract

Administration of a degraded iota carrageenan in drinking water to rhesus monkeys resulted in storage of carrageenan in colonic submucosal macrophage lysosomes that persisted even after prolonged recovery. This storage was accompanied by alterations in lysosomal function (appearance of cytoplasmic acid phosphatase, failure of HRP laden endocytic vesicles to fuse with the carrageenan laden lysosomes). Macrophage necrosis and leukocytic infiltration were also observed. Administration of a native (HMR) carrageenan caused no alterations in colonic submucosal macrophages, nor was any storage of HMR observed.

摘要

给恒河猴饮用含有降解的ι-卡拉胶的水，结果导致卡拉胶在结肠黏膜下巨噬细胞溶酶体中蓄积，即使在长时间恢复后这种蓄积仍持续存在。这种蓄积伴随着溶酶体功能的改变（细胞质酸性磷酸酶的出现、载有辣根过氧化物酶的内吞小泡未能与载有卡拉胶的溶酶体融合）。还观察到巨噬细胞坏死和白细胞浸润。给予天然（HMR）卡拉胶未引起结肠黏膜下巨噬细胞的改变，也未观察到HMR的任何蓄积。