Yang Y H, Fu S G, Peng H, Shen A D, Yue S J, Go Y F, Yuan L, Jiang Z F
Laboratory of Microbiology and Immunology, Beijing Pediatric Institute, Beijing Children's Hospital, China.
Pediatr Infect Dis J. 1993 Dec;12(12):986-8. doi: 10.1097/00006454-199312000-00004.
There is scant information about the etiology and epidemiology of bacterial diseases of infants and children in China because of very little success with bacterial culture. This study describes the severity of abuse of antibiotics among Chinese pediatricians and this abuse's potential interference in determining the etiology of bacterial diseases. According to a survey in Beijing Children's Hospital more than 98% of the patients in the Outpatient Department who were diagnosed with common cold were given antibiotics by physicians. More than one-third of the patients had been taking antibiotics before coming to the hospital. Using a sensitive Staphylococcus aureus assay we found that 70% of blood samples and 43% of cerebrospinal fluid samples from the patients with bacterial meningitis and pneumonia contained antibacterial activity. Bacteria were recovered significantly less often from the samples with antibacterial activity than from those who did not from which antibiotic was not recovered, both in blood (5.3% vs. 12.5%) and in cerebrospinal fluid (2.5% vs. 14.8%). This study indicates that antibiotic abuse is a severe problem in China and that judicious use of antibiotics is urgently needed.
由于细菌培养成功率很低，关于中国婴幼儿细菌性疾病的病因学和流行病学的信息很少。本研究描述了中国儿科医生中抗生素滥用的严重程度以及这种滥用对确定细菌性疾病病因的潜在干扰。根据北京儿童医院的一项调查，门诊中超过98%被诊断为普通感冒的患者被医生使用了抗生素。超过三分之一的患者在来医院之前一直在服用抗生素。使用敏感的金黄色葡萄球菌检测方法，我们发现患有细菌性脑膜炎和肺炎的患者中，70%的血液样本和43%的脑脊液样本含有抗菌活性。在有抗菌活性的样本中，细菌的培养回收率明显低于未检测到抗生素的样本，血液样本中分别为5.3%和12.5%，脑脊液样本中分别为2.5%和14.8%。本研究表明，抗生素滥用在中国是一个严重问题，迫切需要合理使用抗生素。
