Gaulier A, Boccon-Gibod L, Sabatier P, Lucas G
Service d'Anatomie et Cytologie Pathologiques, Hôpital V. Dupouy, Argenteuil, France.
Pediatr Pathol. 1993 Nov-Dec;13(6):741-9. doi: 10.3109/15513819309048261.
A unilateral cystic renal process discovered prenatally was removed in a neonate. Dysplastic cysts were associated with diffuse (both intra- and perilobar) nephroblastomatosis. We describe a comprehensive immunohistological study confirming the transition observed on simple histology between the different structures: nephrogenic rests (CD9+, CD24+/-, CD56+/-), glomeruloid bodies (CD10++, CD35++), ducts lined by columnar epithelium (CD9+, CD24+, CD56++), cysts lined by cuboidal or thin epithelium (some cells CD10+, CD26+, others EMA+, CD24+). Although no typical S-shaped bodies are seen, small cysts and ducts with a columnar epithelium are considered similar. The dysplastic primitive ducts are KL1++, vimentin+/-, CD9+, CD24+. With a view to assessing dysplastic preneoplastic potential, the value of CD56 and Ki67 as activation antigens with possible prognostic significance is discussed.
一名新生儿切除了产前发现的单侧囊性肾脏病变。发育异常的囊肿与弥漫性（叶内和叶周）肾母细胞瘤病相关。我们描述了一项全面的免疫组织学研究，证实了在简单组织学上观察到的不同结构之间的转变：肾源性残留（CD9+、CD24+/-、CD56+/-）、肾小球样体（CD10++、CD35++）、柱状上皮衬里的导管（CD9+、CD24+、CD56++）、立方上皮或扁平上皮衬里的囊肿（一些细胞CD10+、CD26+，其他细胞EMA+、CD24+）。尽管未见到典型的S形小体，但具有柱状上皮的小囊肿和导管被认为相似。发育异常的原始导管KL1++、波形蛋白+/-、CD9+、CD24+。为了评估发育异常的肿瘤前潜能，讨论了CD56和Ki67作为可能具有预后意义的激活抗原的价值。
