CD8β链在CD8谱系T细胞阳性选择中的需求。
Requirement for CD8 beta chain in positive selection of CD8-lineage T cells.
作者信息
Nakayama K, Nakayama K, Negishi I, Kuida K, Louie M C, Kanagawa O, Nakauchi H, Loh D Y
机构信息
Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110.
出版信息
Science. 1994 Feb 25;263(5150):1131-3. doi: 10.1126/science.8108731.
CD8 is either an alpha alpha homodimer or an alpha beta heterodimer, although most peripheral CD8-lineage T cells express only the CD8 alpha beta heterodimer. The physiological function of CD8 beta was elucidated with mice that were chimeric for the homozygous disruption of the CD8 beta gene. The CD8 beta-1- T cells developed normally to CD4+CD8+ stage, but did not efficiently differentiate further, which resulted in few peripheral CD8+ T cells. The number of peripheral CD8+ T cells was restored by transfer of an exogenous CD8 beta gene into CD8 beta-deficient T cells. Thus, CD8 beta is necessary for the maturation of CD8+ T cells.
CD8 要么是αα同二聚体，要么是αβ异二聚体，不过大多数外周 CD8 谱系 T 细胞仅表达 CD8αβ异二聚体。通过对 CD8β基因纯合缺失的嵌合小鼠，阐明了 CD8β的生理功能。CD8β-1- T 细胞正常发育至 CD4+CD8+阶段，但不能有效进一步分化，导致外周 CD8+ T 细胞数量稀少。通过将外源性 CD8β基因导入 CD8β缺陷型 T 细胞，可恢复外周 CD8+ T 细胞数量。因此，CD8β对于 CD8+ T 细胞的成熟是必需的。
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