TL 和 CD8αα：黏膜免疫中的神秘伙伴。
TL and CD8αα: Enigmatic partners in mucosal immunity.
机构信息
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232, USA.
出版信息
Immunol Lett. 2010 Nov 30;134(1):1-6. doi: 10.1016/j.imlet.2010.09.004. Epub 2010 Sep 17.
Abstract
The intestinal mucosa represents a large surface area that is in contact with an immense antigenic load. The immune system associated with the intestinal mucosa needs to distinguish between innocuous food antigens, commensal microorganisms, and pathogenic microorganisms, without triggering an exaggerated immune response that may lead to excessive inflammation and/or development of inflammatory bowel disease. The thymus leukemia (TL) antigen and CD8αα are interacting surface molecules that are expressed at the frontline of the mucosal immune system: TL is expressed in intestinal epithelial cells (IEC) whereas CD8αα is expressed in lymphocytes, known as intraepithelial lymphocytes, that reside in between the IEC. In this review we discuss the significance of the interaction between TL and CD8αα in mucosal immunity during health and disease.
摘要
肠黏膜代表了与巨大抗原负荷接触的大面积表面。与肠黏膜相关的免疫系统需要区分无害的食物抗原、共生微生物和病原微生物，而不会引发可能导致过度炎症和/或炎症性肠病发展的过度免疫反应。胸腺白血病 (TL) 抗原和 CD8αα 是相互作用的表面分子，它们在黏膜免疫系统的前沿表达：TL 在肠上皮细胞 (IEC) 中表达，而 CD8αα 在淋巴细胞中表达，称为上皮内淋巴细胞，它们存在于 IEC 之间。在这篇综述中，我们讨论了 TL 和 CD8αα 在健康和疾病期间黏膜免疫中的相互作用的意义。
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