Plaut A G, Gilbert J V, Artenstein M S, Capra J D
Science. 1975 Dec 12;190(4219):1103-5. doi: 10.1126/science.810892.
The gonococcus and meningococcus, which infect human mucosal surfaces, elaborate a highly specific proteolytic enzyme which cleaves the immunoglobulin A1 subclass of the principal mucosal antibody, immunoglobulin A (IgA). The susceptible Pro-Thr bond lies in a unique region of the IgA heavy chain; the IgA2 subclass, lacking this peptide bond, is enzyme resistant.
感染人类黏膜表面的淋球菌和脑膜炎球菌会产生一种高度特异性的蛋白水解酶，该酶可切割主要黏膜抗体免疫球蛋白A（IgA）的免疫球蛋白A1亚类。敏感的脯氨酸-苏氨酸键位于IgA重链的一个独特区域；缺乏这种肽键的IgA2亚类对该酶具有抗性。
