Haba R, Kobayashi S, Miki H, Hirakawa E, Saoo K, Iwai T, Mori S, Ohmori M
First Department of Pathology, Kagawa Medical School, Japan.
Acta Pathol Jpn. 1993 Dec;43(12):774-8. doi: 10.1111/j.1440-1827.1993.tb02565.x.
A case of polymorphous low-grade adenocarcinoma (PLGA) in the submandibular gland is reported. A 72 year old woman presented with a 5 year history of a gradually expanding tumor in the submandibular region. The surgical specimen revealed a relatively well demarcated tumor, 35 x 35 x 20 mm in size. Macroscopically, necrosis and hemorrhage were not seen in the solid tumor. Histologically, the tumor growth pattern was variable, composed of tubular, papillary, solid, trabecular and cribriform structures. Immunohistochemically, some tumor cells were positive for epithelial membrane antigen (EMA), S-100 protein, keratin, and carcinoembryonic antigen (CEA). Electron microscopically, prominent microvilli projected into the luminal spaces, and basal lamina and hemidesmosomes were seen in the tumor cells adjacent to the connective tissues. The submandibular gland is an extremely rare location for PLGA. To the authors' knowledge, this is the first case of its kind reported in the English literature.
报告了1例发生于下颌下腺的多形性低度恶性腺癌（PLGA）。一名72岁女性，下颌下区肿物逐渐增大5年。手术标本显示肿瘤边界相对清晰，大小为35×35×20mm。大体上，实性肿瘤未见坏死和出血。组织学上，肿瘤生长模式多样，由管状、乳头状、实性、小梁状和筛状结构组成。免疫组化显示，部分肿瘤细胞上皮膜抗原（EMA）、S-100蛋白、角蛋白和癌胚抗原（CEA）呈阳性。电镜下，可见突出的微绒毛伸入管腔间隙，与结缔组织相邻的肿瘤细胞可见基底膜和半桥粒。PLGA发生于下颌下腺极为罕见。据作者所知，这是英文文献中首例此类报道。
