Ohkubo S, Torisaki M, Higashide T, Mochizuki K, Ishibashi Y
Department of Ophthalmology, Kanazawa University School of Medicine, Ishikawa-ken, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Jan;98(1):103-10.
A case of fungal endophthalmitis caused by Paecilomyces lilacinus after cataract surgery is reported. An 84-year-old woman had been suffering from diabetes mellitus and hypertension. She underwent an uncomplicated extracapsular cataract extraction with implantation of a posterior chamber intraocular lens in the right eye. Approximately one month after the surgery iritis was noted, and treated systemically and topically with corticosteroids and antibiotics. The inflammation was improved by these therapies at first, but worsened when the dose of oral corticosteroid was reduced. White fluffy exudates were present on the iris near the chamber angle with the hypopyon. Removal of the intraocular lens, vitrectomy and medicinal therapy were undertaken. The eye was salvaged but the final visual acuity was counting fingers. Paecilomyces lilacinus was identified from the intraocular specimen taken at the time of surgery. The clinical effects and the results of in-vitro sensitivity test showed that fluconazole and amphotericin B were ineffective, and that econazole, thimerosal and miconazole were effective.
报道了1例白内障手术后由淡紫拟青霉引起的真菌性眼内炎。一名84岁女性患有糖尿病和高血压。她右眼接受了无并发症的囊外白内障摘除术并植入后房型人工晶状体。术后约1个月发现虹膜炎,全身及局部用皮质类固醇和抗生素治疗。起初这些治疗使炎症有所改善,但当口服皮质类固醇剂量减少时炎症恶化。房角附近的虹膜上出现白色绒毛状渗出物并伴有前房积脓。进行了人工晶状体取出术、玻璃体切除术和药物治疗。患眼得以挽救,但最终视力为指数。从手术时采集的眼内标本中鉴定出淡紫拟青霉。临床疗效和体外药敏试验结果表明,氟康唑和两性霉素B无效,而益康唑、硫柳汞和咪康唑有效。