Webb D I, Bundtzen J L
Pathology Department, Providence Hospital, Anchorage, Alaska 99508.
Alaska Med. 1993 Jul-Sep;35(3):216-7, 224.
This case report concerns a woman thought to have a low blood count myelodysplastic syndrome who responded poorly to cytosine arabinoside. She was treated with Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and had an adverse reaction resembling a capillary leak syndrome. Later on, an episode of post-transfusion hemoglobinuria led to the correct diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). This case report suggests an adverse effect of GM-CSF on PNH.
本病例报告涉及一名被认为患有低血细胞计数骨髓增生异常综合征的女性，她对阿糖胞苷反应不佳。她接受了粒细胞巨噬细胞集落刺激因子（GM-CSF）治疗，并出现了类似毛细血管渗漏综合征的不良反应。后来，一次输血后血红蛋白尿发作导致了阵发性夜间血红蛋白尿（PNH）的正确诊断。本病例报告提示GM-CSF对PNH有不良影响。
