McManus R P, O'Hair D P, Komorowski R, Scott J P
Department of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee 53226.
Ann N Y Acad Sci. 1993 Nov 30;696:281-4.
ABO matched cynomolgus monkey to baboon heterotopic xenografts were performed using three different immunosuppressant regimens. Group 1 (n = 4) baboons, which did not receive immunosuppression, had a mean graft survival of 9 days. Group 2 (n = 6) received cyclosporine (CsA) and methylprednisolone acetate which prolonged graft survival to an average of 78 days. Group 3 (n = 5) received CsA, Pred, and azathioprine (Aza) as well as steroid pulses and antithymocyte globulin (ATG) for rejection episodes. Survival in this group averaged 94 days. In Group 4 (n = 3), the same regimen as group 3 was used; however, Mycophenolate Mofetil was substituted for Aza. This resulted in a mean survival of 296 days. Histologic examination of the coronary vasculature in baboons treated with Mofetil showed a reduction in vascular pathologic changes when compared to those treated with Aza. Long-term cardiac xenograft survival is possible using currently available immunosuppressive agents.
使用三种不同的免疫抑制方案进行了ABO血型匹配的食蟹猴到狒狒的异位异种移植。第1组（n = 4）的狒狒未接受免疫抑制，移植物平均存活9天。第2组（n = 6）接受环孢素（CsA）和醋酸甲泼尼龙，移植物存活期延长至平均78天。第3组（n = 5）接受CsA、泼尼松（Pred）和硫唑嘌呤（Aza）以及用于治疗排斥反应的类固醇脉冲和抗胸腺细胞球蛋白（ATG）。该组的平均存活期为94天。第4组（n = 3）使用与第3组相同的方案；然而，霉酚酸酯替代了Aza。这导致平均存活期为296天。与用Aza治疗的狒狒相比，用霉酚酸酯治疗的狒狒冠状动脉血管的组织学检查显示血管病理变化减少。使用目前可用的免疫抑制剂可以实现长期心脏异种移植存活。
