新型碳青霉烯类抗生素BO-2727的体外活性，其具有强大的抗假单胞菌活性。
In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity.
作者信息
Nakagawa S, Hashizume T, Matsuda K, Sanada M, Okamoto O, Fukatsu H, Tanaka N
机构信息
Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
出版信息
Antimicrob Agents Chemother. 1993 Dec;37(12):2756-9. doi: 10.1128/AAC.37.12.2756.
Abstract
BO-2727, a new 1-beta-methyl-carbapenem, was active at concentrations of 6.25 micrograms/ml or less against gram-positive and gram-negative bacteria, including some imipenem- and/or meropenem-resistant (MICs, > or = 12.5 micrograms/ml) Pseudomonas aeruginosa strains, against which it proved generally fourfold more active than imipenem and meropenem. BO-2727's antipseudomonal activity and its broad spectrum merit further investigation for clinical use by itself, since it was stable in the presence of renal dehydropeptidase I.
摘要
BO - 2727是一种新型的1-β-甲基碳青霉烯类抗生素，在浓度为6.25微克/毫升或更低时，对革兰氏阳性菌和革兰氏阴性菌具有活性，包括一些对亚胺培南和/或美罗培南耐药（最低抑菌浓度≥12.5微克/毫升）的铜绿假单胞菌菌株，事实证明它对这些菌株的活性通常比亚胺培南和美罗培南高四倍。BO - 2727的抗假单胞菌活性及其广谱性值得对其自身临床应用进行进一步研究，因为它在肾脱氢肽酶I存在的情况下是稳定的。
相似文献
1
In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity.新型碳青霉烯类抗生素BO-2727的体外活性，其具有强大的抗假单胞菌活性。
Antimicrob Agents Chemother. 1993 Dec;37(12):2756-9. doi: 10.1128/AAC.37.12.2756.
2
In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I.新型碳青霉烯类抗生素LJC10,627对脱氢肽酶I具有高稳定性的体外活性。
Antimicrob Agents Chemother. 1990 Jun;34(6):994-1000. doi: 10.1128/AAC.34.6.994.
3
[Preclinical evaluation of meropenem, a new parenteral carbapenem].[新型胃肠外碳青霉烯类药物美罗培南的临床前评估]
New Microbiol. 1995 Oct;18 Suppl:19S-31S.
4
In vitro and in vivo evaluation of BO-2727 against imipenem- and/or meropenem-resistant Pseudomonas aeruginosa.BO-2727 对亚胺培南和/或美罗培南耐药铜绿假单胞菌的体外和体内评价
J Antibiot (Tokyo). 1997 Feb;50(2):135-8. doi: 10.7164/antibiotics.50.135.
5
In vitro activity of BMS-181139, a new carbapenem with potent antipseudomonal activity.新型碳青霉烯类药物BMS-181139的体外活性，该药物具有强大的抗假单胞菌活性。
Antimicrob Agents Chemother. 1995 Feb;39(2):380-5. doi: 10.1128/AAC.39.2.380.
6
In vitro and in vivo antibacterial activities of ER-35786, a new antipseudomonal carbapenem.新型抗假单胞菌碳青霉烯类药物ER-35786的体外和体内抗菌活性
Antimicrob Agents Chemother. 1997 Feb;41(2):298-307. doi: 10.1128/AAC.41.2.298.
7
Heteroaryliumthio substituted carbapenem derivatives: synthesis and in vitro activity of 1 beta-methyl-2-(dihydropyrrolotriazoliumthio)carbapenems.杂芳硫基取代的碳青霉烯衍生物：1β-甲基-2-(二氢吡咯并三唑硫基)碳青霉烯的合成及体外活性
J Antibiot (Tokyo). 1993 Dec;46(12):1866-82. doi: 10.7164/antibiotics.46.1866.
8
In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I.对脱氢肽酶I稳定的碳青霉烯类抗生素SM-7338的体外抗菌活性
Antimicrob Agents Chemother. 1989 Feb;33(2):215-22. doi: 10.1128/AAC.33.2.215.
9
Antibacterial properties of BO-2727, a new carbapenem antibiotic.
J Antimicrob Chemother. 1997 Aug;40(2):195-203. doi: 10.1093/jac/40.2.195.
10
Antibacterial properties of meropenem towards clinical isolates, beta-lactamase producers and laboratory mutants.美罗培南对临床分离株、β-内酰胺酶产生菌及实验室突变株的抗菌特性。
J Antimicrob Chemother. 1989 Sep;24 Suppl A:197-205. doi: 10.1093/jac/24.suppl_a.197.
引用本文的文献
1
Comparative pharmacokinetics of the carbapenems: clinical implications.碳青霉烯类药物的比较药代动力学：临床意义。
Clin Pharmacokinet. 2000 Sep;39(3):185-201. doi: 10.2165/00003088-200039030-00002.
2
In vitro activities of novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems with potent activities against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.新型反式-3,5-二取代吡咯烷硫基-1β-甲基碳青霉烯类化合物对耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌的体外活性
Antimicrob Agents Chemother. 2000 Mar;44(3):489-95. doi: 10.1128/AAC.44.3.489-495.2000.
3
In vitro activities of aminomethyl-substituted analogs of novel tetrahydrofuranyl carbapenems.新型四氢呋喃基碳青霉烯类氨基甲基取代类似物的体外活性
Antimicrob Agents Chemother. 1999 Mar;43(3):454-9. doi: 10.1128/AAC.43.3.454.
4
Antimicrobial activity of DU-6681a, a parent compound of novel oral carbapenem DZ-2640.新型口服碳青霉烯类药物DZ-2640的母体化合物DU-6681a的抗菌活性
Antimicrob Agents Chemother. 1997 Jun;41(6):1260-8. doi: 10.1128/AAC.41.6.1260.
5
In vitro and in vivo antibacterial activities of ER-35786, a new antipseudomonal carbapenem.新型抗假单胞菌碳青霉烯类药物ER-35786的体外和体内抗菌活性
Antimicrob Agents Chemother. 1997 Feb;41(2):298-307. doi: 10.1128/AAC.41.2.298.
6
PCR detection of metallo-beta-lactamase gene (blaIMP) in gram-negative rods resistant to broad-spectrum beta-lactams.对耐广谱β-内酰胺类的革兰氏阴性杆菌进行金属β-内酰胺酶基因（blaIMP）的聚合酶链反应检测
J Clin Microbiol. 1996 Dec;34(12):2909-13. doi: 10.1128/jcm.34.12.2909-2913.1996.
7
Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa.铜绿假单胞菌NfxB突变体中敏感性与OprJ产生之间的定量相关性。
Antimicrob Agents Chemother. 1996 Apr;40(4):909-13. doi: 10.1128/AAC.40.4.909.
8
Imipenem/cilastatin: an update of its antibacterial activity, pharmacokinetics and therapeutic efficacy in the treatment of serious infections.亚胺培南/西司他丁：其抗菌活性、药代动力学及治疗严重感染疗效的最新进展
Drugs. 1996 Jan;51(1):99-136. doi: 10.2165/00003495-199651010-00008.
9
In vitro antibacterial activity and beta-lactamase stability of a new carbapenem, BO-2727.新型碳青霉烯类药物BO - 2727的体外抗菌活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1995 Oct;39(10):2331-6. doi: 10.1128/AAC.39.10.2331.
10
Mechanism of enhanced antipseudomonal activity of BO-2727, a new injectable 1-beta-methyl carbapenem.新型注射用1-β-甲基碳青霉烯类药物BO-2727抗假单胞菌活性增强的机制
Antimicrob Agents Chemother. 1995 Mar;39(3):702-6. doi: 10.1128/AAC.39.3.702.
本文引用的文献
1
MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities.MK0787（N-亚胺甲酰硫霉素）：体内外活性评估
Antimicrob Agents Chemother. 1980 Jun;17(6):993-1000. doi: 10.1128/AAC.17.6.993.
2
Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics.一种新型稳定化硫霉素（N-甲脒基硫霉素）与其他抗生素相比的抗菌活性。
Antimicrob Agents Chemother. 1980 Jun;17(6):912-7. doi: 10.1128/AAC.17.6.912.
3
Purification and properties of an inducible cephalosporinase from Pseudomonas maltophilia GN12873.嗜麦芽窄食单胞菌GN12873中一种诱导型头孢菌素酶的纯化及特性
Antimicrob Agents Chemother. 1984 Mar;25(3):362-5. doi: 10.1128/AAC.25.3.362.
4
Thienamycin: development of imipenen-cilastatin.硫霉素：亚胺培南-西司他丁的研发
J Antimicrob Chemother. 1983 Dec;12 Suppl D:1-35. doi: 10.1093/jac/12.suppl_d.1.
5
In vitro activity against aerobic and anaerobic gram-positive and gram-negative bacteria and beta-lactamase stability of RS-533, a novel carbapenem.新型碳青霉烯类药物RS-533对需氧和厌氧革兰氏阳性及革兰氏阴性菌的体外活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1986 Dec;30(6):828-34. doi: 10.1128/AAC.30.6.828.
6
Emergence of resistance to imipenem during therapy for Pseudomonas aeruginosa infections.铜绿假单胞菌感染治疗期间对亚胺培南耐药性的出现。
J Infect Dis. 1986 Aug;154(2):289-94. doi: 10.1093/infdis/154.2.289.
7
In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338.新型碳青霉烯类药物SM-7338的体外活性及β-内酰胺酶稳定性
Antimicrob Agents Chemother. 1989 Jul;33(7):1009-18. doi: 10.1128/AAC.33.7.1009.
8
Characterization of beta-lactamases.β-内酰胺酶的特性分析
Antimicrob Agents Chemother. 1989 Mar;33(3):259-63. doi: 10.1128/AAC.33.3.259.
9
In vitro antibacterial activity and beta-lactamase stability of the new carbapenem SM-7338.
Eur J Clin Microbiol Infect Dis. 1989 Oct;8(10):908-16. doi: 10.1007/BF01963782.
10
In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I.新型碳青霉烯类抗生素LJC10,627对脱氢肽酶I具有高稳定性的体外活性。
Antimicrob Agents Chemother. 1990 Jun;34(6):994-1000. doi: 10.1128/AAC.34.6.994.
Zotero 插件