Hamdan W, Ramzan I
Department of Pharmacy, University of Sydney, NSW, Australia.
In Vivo. 1993 Sep-Oct;7(5):461-2.
The effect of the anti-fungal agent fluconazole on neuromuscular transmission was evaluated in vivo using the rat sciatic nerve-anterior tibialis muscle preparation. Fluconazole, 20 mg/kg, administered orally one hour before the experiment failed to alter the infusion rate of succinylcholine required to maintain 50% neuromuscular paralysis. In addition, the rate of recovery from succinylcholine induced paralysis or the final recovery of the muscle twitch response did not differ between control and fluconazole treated rats. Fluconazole alone at 20 or 40 mg/kg I.V. also failed to produce any observable effect in neuromuscular function. Acute fluconazole, therefore, at human therapeutic concentrations, fails to alter neuromuscular transmission in vivo in rats.
使用大鼠坐骨神经-胫前肌标本在体内评估抗真菌剂氟康唑对神经肌肉传递的影响。在实验前1小时口服20mg/kg氟康唑，未能改变维持50%神经肌肉麻痹所需的琥珀酰胆碱输注速率。此外，对照组和氟康唑治疗组大鼠从琥珀酰胆碱诱导的麻痹中恢复的速率或肌肉抽搐反应的最终恢复情况并无差异。静脉注射20或40mg/kg的氟康唑单独使用时，对神经肌肉功能也未产生任何可观察到的影响。因此，在人体治疗浓度下的急性氟康唑不会改变大鼠体内的神经肌肉传递。
