尼扎替丁对神经肌肉传递的作用。

The effect of nizatidine on neuromuscular transmission.

作者信息

Bossa R, Baggio G, Caffero L, Castelli M, Chiericozzi M, Efstathiu G, Galatulas I

机构信息

Department of Pharmacology, Chemotherapy and Toxicology Emilio Trabucchi, University of Milan, Italy.

出版信息

In Vivo. 1992 Nov-Dec;6(6):597-600.

PMID:1338367

Abstract

The effect of the H2-receptor antagonist, nizatidine, on neuromuscular transmission was investigated using sciatic nerve-gastrocnemius muscle preparations of rat in vivo. Nizatidine, administered by i.v. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and the aminoglycoside antibiotic, kanamycin. Moreover, the drug alone is capable of producing a blockade on preparations stimulated at high frequency. The neuromuscular blockade induced by nizatidine is reversed by 4-aminopyridine but not by dimaprit.

摘要

使用大鼠体内坐骨神经-腓肠肌标本研究了H2受体拮抗剂尼扎替丁对神经肌肉传递的影响。通过静脉注射给予尼扎替丁，可增强d-筒箭毒碱、泮库溴铵和氨基糖苷类抗生素卡那霉素诱导的神经肌肉阻滞。此外，该药物单独使用时能够对高频刺激的标本产生阻滞作用。尼扎替丁诱导的神经肌肉阻滞可被4-氨基吡啶逆转，但不能被二甲普利逆转。