Penna A C, Dawson K P, Manglick P, Tam J
Department of Paediatrics, University of Sydney, Australia.
Acta Paediatr. 1993 Nov;82(11):963-6. doi: 10.1111/j.1651-2227.1993.tb12609.x.
We measured plasma salbutamol concentrations in 35 children with acute asthma attacks before and after nebulizer therapy. The main finding was that older children had higher concentrations than younger children, despite similar dosage regimens. There was no influence of severity of the asthma attack on the following measures: pre- and post-nebulizer concentrations, absolute and percentage change in salbutamol levels with therapy. We conclude that the theoretical risks of high concentrations in young children were not found and we suggest that the very young may indeed require higher doses due to possible problems in nebulizer technique or differences in kinetics.
我们测量了35名急性哮喘发作儿童在雾化治疗前后的血浆沙丁胺醇浓度。主要发现是，尽管给药方案相似，但年龄较大的儿童浓度高于年龄较小的儿童。哮喘发作的严重程度对以下指标没有影响：雾化前和雾化后的浓度、治疗过程中沙丁胺醇水平的绝对变化和百分比变化。我们得出结论，未发现幼儿高浓度的理论风险，并且我们认为，由于雾化技术可能存在的问题或动力学差异，非常年幼的儿童可能确实需要更高的剂量。
