网膜-肠系膜炎性假瘤。一例肿瘤遗传改变及单克隆性的细胞遗传学证明。
Omental-mesenteric inflammatory pseudotumor. Cytogenetic demonstration of genetic changes and monoclonality in one tumor.
作者信息
Treissman S P, Gillis D A, Lee C L, Giacomantonio M, Resch L
机构信息
Department of General Surgery, Isaac Walton Killam Children's Hospital, Halifax, Nova Scotia, Canada.
出版信息
Cancer. 1994 Mar 1;73(5):1433-7. doi: 10.1002/1097-0142(19940301)73:5<1433::aid-cncr2820730518>3.0.co;2-f.
BACKGROUND
Extrapulmonary inflammatory pseudotumor (plasma cell granuloma) is an uncommon lesion in adults and children, and little is known either of its etiology or clinical characteristics. However, it remains a significant source of morbidity to patients and confusion to clinicians.
METHODS
Case reports are presented of three patients with intraabdominal inflammatory pseudotumor who recently underwent surgery. A review of the recent world literature is also presented. Clinical and laboratory characteristics of omental-mesenteric inflammatory pseudotumor are reviewed along with a discussion of its etiology.
RESULTS
Cytogenetic data from cells of one patient show a derivative chromosome evolved from a translocation between the long arm of chromosome 2 and the short arm of chromosome 9 [(2;9)(q1,3;p2,2)].
CONCLUSIONS
The lesion is monoclonal, and genetic changes may play a crucial role in the development of this neoplasm. Omental-mesenteric inflammatory pseudotumor appears to represent a distinct clinicopathologic entity as a benign neoplasm in children.
背景
肺外炎性假瘤（浆细胞肉芽肿）在成人和儿童中均为罕见病变，其病因及临床特征鲜为人知。然而，它仍是患者发病的重要原因，也给临床医生带来困惑。
方法
报告了3例近期接受手术的腹腔炎性假瘤患者的病例。同时对近期世界文献进行了综述。回顾了网膜-肠系膜炎性假瘤的临床和实验室特征，并对其病因进行了讨论。
结果
1例患者细胞的细胞遗传学数据显示，一条衍生染色体由2号染色体长臂与9号染色体短臂之间的易位演变而来[(2;9)(q1,3;p2,2)]。
结论
该病变为单克隆性，基因改变可能在该肿瘤的发生发展中起关键作用。网膜-肠系膜炎性假瘤似乎是儿童良性肿瘤中一种独特的临床病理实体。
Zotero 插件