[Treatment of rapid progressive glomerulonephritis (RPGN) with pulse methylprednisolone (MP) and urokinase (UK): a renal rebiopsy study].

We have performed a case controlled study on the morphological and immunopathological alterations which can be induced by pulse MP combined with UK in RPGN by means of before and post therapy renal biopsies. The results showed renal function and histologic patterns improved. The histopathological (endothelium and mesangial cell proliferation, crescent and interstitial infiltration) and immunopathological (deposition of IgG, C3, Collegen type III, IV, Laminin and FN.) changes improved in all the patients after treatment with pulse MP and UK. The results indicated that pulse MP and UK therapy seems to be useful in treatment of RPGN in early stage and renal rebiopsy could lead to a better understanding of RPGN outcome.