Sola F, Farao M, Marsiglio A, Mariani M, Grandi M
Farmitalia Carlo Erba Research Institute, Research and Development/Experimental Oncology Laboratory, Nerviano, Italy.
Invasion Metastasis. 1993;13(3):163-8.
The effect of suramin on B16F10 melanoma lung colonies and M5076 reticulosarcoma liver metastasis formation was evaluated in C57B1/6 female mice. Single i.v. doses of 200 mg/kg suramin given 48 and 24 h prior to tumor cell injection significantly inhibited metastasis formation in both models, whereas the same treatment administered 24 h after cell injection was ineffective. A dose-response experiment in the B16F10 melanoma model showed that inhibition of lung colony formation was still significant with 50 mg/kg pretreatment, whereas a borderline effect was observed at 10 mg/kg. At the effective doses, the plasma and organ concentrations of suramin were far below those needed to exert significant in vitro cytotoxic or cytostatic effects on B16F10 and M5076 cells. Thus, in addition to the antineoplastic effect of suramin our results indicate a potential antimetastatic role for this compound.
在C57B1/6雌性小鼠中评估了苏拉明对B16F10黑色素瘤肺集落和M5076网状细胞肉瘤肝转移形成的影响。在肿瘤细胞注射前48小时和24小时静脉注射200mg/kg的单剂量苏拉明，在两种模型中均显著抑制转移形成，而在细胞注射后24小时给予相同处理则无效。B16F10黑色素瘤模型中的剂量反应实验表明，50mg/kg预处理对肺集落形成的抑制作用仍然显著，而在10mg/kg时观察到临界效应。在有效剂量下，苏拉明的血浆和器官浓度远低于对B16F10和M5076细胞产生显著体外细胞毒性或细胞抑制作用所需的浓度。因此，除了苏拉明的抗肿瘤作用外，我们的结果还表明该化合物具有潜在的抗转移作用。
