采用99mTc-六甲基丙烯胺肟单光子发射计算机断层扫描结合133Xe脑血流量定量测定脑血流量。

Quantitation of rCBF by 99mTc-hexamethylpropyleneamine oxime single photon emission computed tomography combined with 133Xe CBF.

作者信息

Isaka Y, Itoi Y, Imaizumi M, Ashida K, Okamoto M, Iiji O

机构信息

Department of Nuclear Medicine, Osaka National Hospital, Japan.

出版信息

J Cereb Blood Flow Metab. 1994 Mar;14(2):353-7. doi: 10.1038/jcbfm.1994.44.

DOI:10.1038/jcbfm.1994.44

PMID:8113331

Abstract

A simple, noninvasive method of measuring CBF that uses single photon emission computed tomography (SPECT) of 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) and whole-brain CBF obtained by 133Xe clearance technique was developed. SPECT data were normalized to the count density of HMPAO uptake in the whole brain and then converted to the absolute units of CBF by multiplying average CBF in the whole brain obtained by 133Xe. Mean CBF values in healthy volunteers (n = 12) were 49 +/- 7 and 30 +/- 5 ml 100 g-1 min-1 for gray matter and white matter, respectively, with a global flow value of 45 +/- 5 ml 100 g-1 min-1. The mean flow value was 19 +/- 7 ml 100 g-1 min-1 for the core of the infarct and 31 +/- 5 ml 100 g-1 min-1 for the contralateral region (n = 13). CBF values were reproducible for all brain regions. The method was convenient to use and suitable for the routine measurement of regional CBF in normal and pathologic states.

摘要

开发了一种简单、无创的测量脑血流量（CBF）的方法，该方法使用99m锝-六甲基丙烯胺肟（99mTc-HMPAO）单光子发射计算机断层扫描（SPECT）以及通过133氙清除技术获得的全脑CBF。SPECT数据被归一化为全脑HMPAO摄取的计数密度，然后通过乘以133氙获得的全脑平均CBF转换为CBF的绝对单位。12名健康志愿者灰质和白质的平均CBF值分别为49±7和30±5 ml·100 g-1·min-1，全脑血流量值为45±5 ml·100 g-1·min-1。梗死核心的平均血流量值为19±7 ml·100 g-1·min-1，对侧区域为31±5 ml·100 g-1·min-1（n = 13）。所有脑区的CBF值均可重复。该方法使用方便，适用于正常和病理状态下区域CBF的常规测量。