C R Acad Hebd Seances Acad Sci D. 1975 Mar 3;280(9):1161-3.
We have shown the presence of a "Cross Reacting Material" for Lactate Dehydrogenase in liver of very old rats. Partial hepatectomy, followed by hepatic regeneration increases the specific activity of the enzyme, which becomes equal to that of Lactate Dehydrogenase of rat liver. Consequently, aging seems to be a cellular phenomenon and not a consequence of the accumulation of errors in transcription or translation.
我们已经证实在非常老龄大鼠的肝脏中存在一种与乳酸脱氢酶发生交叉反应的物质。部分肝切除术后，随着肝脏再生，该酶的比活性增加，变得与大鼠肝脏乳酸脱氢酶的比活性相当。因此，衰老似乎是一种细胞现象，而非转录或翻译错误积累的结果。
