Klaassen C D
CRC Crit Rev Toxicol. 1975 Oct;4(1):1-30. doi: 10.1080/10408447509163833.
The biliary route is very important for the elimination of some foreign compounds from the body. For many of these compounds, an increase in the rate at which they are excreted into the bile will decrease their toxicity and vice versa. A number of factors which are known to alter the biliary excretion of xenobiotics, as well as the current concepts of the physiological mechanisms responsible for the excretion of foreign compounds, have been enumerated. However, much remains still to be understood; essentially nothing is known at the subcellular level about the biliary excretion of foreign compounds. It has recently been concluded that our knowledge of the biliary excretion of compounds is about 40 years behind that of the renal excretion mechanism.
胆汁途径对于某些外源性化合物从体内的排泄非常重要。对于许多这类化合物，它们排入胆汁的速率增加会降低其毒性，反之亦然。已列举了一些已知会改变外源性物质胆汁排泄的因素，以及负责外源性化合物排泄的生理机制的当前概念。然而，仍有许多有待了解；在亚细胞水平上，对外源性化合物的胆汁排泄基本上一无所知。最近得出的结论是，我们对化合物胆汁排泄的了解比肾脏排泄机制的了解落后约40年。
