Baum W F, Klöditz E, Hesse V, Jahreis G, Schneyer U, Giebler H
Kinderklinik, Martin-Luther-Universität Halle.
Kinderarztl Prax. 1993 Nov;61(9):323-8.
Asthmatic children tend towards hyposomia. Although quite a number of suggestions have been made, the real cause of this phenomenon has not yet been revealed. Investigation of the growth hormone secretion and the IGF-I serum levels aims at clarifying whether an atopy-caused disturbance in the interaction between both the hormones is responsible for retardations in the growth and development of asthmatic children.
In 19 prepubertal extrinsic asthmatics the spontaneous growth hormone secretion was reviewed in form of a 24 h-profile. In addition, the IGF-I serum levels were measured.
With a mean 24 h-secretion of 10.7 +/- 1.0 ng/ml and a maximum growth hormone peak of 39.5 +/- 5.8 ng/ml prepubertal extrinsic asthmatics showed an increased hormone secretion which, however, could not be observed with all the children. The IGF-I mean values were in 11 asthmatics within the normal range, decreased in 5 cases and increased in only 3 children.
哮喘儿童往往身材矮小。尽管已经提出了不少建议，但这一现象的真正原因尚未揭示。对生长激素分泌和血清胰岛素样生长因子-1（IGF-I）水平进行调查，旨在阐明特应性引起的这两种激素之间相互作用的紊乱是否是哮喘儿童生长发育迟缓的原因。
对19例青春期前的外源性哮喘患者，以24小时曲线的形式回顾其自发性生长激素分泌情况。此外，还测量了血清IGF-I水平。
青春期前外源性哮喘患者的生长激素平均24小时分泌量为10.7±1.0 ng/ml，最大峰值为39.5±5.8 ng/ml，显示激素分泌增加，但并非所有儿童均如此。11例哮喘患者的IGF-I平均值在正常范围内，5例降低，仅3例升高。
