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[一例脑内结核瘤:临床特征及磁共振成像表现]

[A case of intracerebral tuberculoma: clinical characteristics and MRI findings].

作者信息

Sakakibara Y, Taguchi Y, Sekino H, Tsukamoto H, Ozawa T, Tadokoro M

机构信息

Second Department of Surgery, St. Marianna University School of Medicine.

出版信息

No Shinkei Geka. 1994 Feb;22(2):161-4.

PMID:8115012
Abstract

A case of intracerebral tuberculoma treated surgically was reported. A 47-year-old man was admitted to our hospital because of progressive left hemiaparesis over the previous 5 months. A computerized tomography scan showed a well enhanced mass associated with a marked perifocal edema. T1 weighted magnetic resonance imaging (MRI) revealed an isosignal ring around the heterogenous low intensity mass. A low intensity area just interior to this ring was also visualized both in T1 and T2 weighted images. Although the clinical course was unusually long, this was diagnosed as a metastatic brain tumor. He underwent a right frontal craniotomy and a well circumscribed, yellowish, firm mass was totally extirpated. Pathohistologically, this mass was considered to be a tuberculoma though the tuberculous bacilli could not be identified in Ziehl-Neelsen staining. His hemiplegia improved much and his ambulation was restored. Since tuberclomas are quite rare in developed countries, the diagnosis of intracerebral tuberculomas would be extremely difficult unless tuberculosis was verified in some other organs. The auxiliary examinations even by using MRI have often given little information which would assist diagnosis. However, based on pathological findings, the ring appearance and low intensity area medial to the ring in the outer part of the tuberculoma shown in MRI of our patient seemed to represent a chronic granulomatous inflammation and gave a clue to rule out the suspicion of metastatic brain tumors. To make a correct diagnosis of intracerebral tuberculomas, multidisciplinary consideration is mandatory.

摘要

报告了一例经手术治疗的脑内结核瘤病例。一名47岁男性因在过去5个月中逐渐出现左侧偏瘫而入住我院。计算机断层扫描显示一个强化良好的肿块,伴有明显的灶周水肿。T1加权磁共振成像(MRI)显示在不均匀的低强度肿块周围有一个等信号环。在T1和T2加权图像中,该环内部的低强度区域也清晰可见。尽管临床病程异常漫长,但该病例最初被诊断为脑转移瘤。患者接受了右额开颅手术,一个边界清晰、淡黄色、质地坚硬的肿块被完全切除。病理组织学检查显示,尽管在齐-尼氏染色中未发现结核杆菌,但该肿块被认为是结核瘤。患者的偏瘫症状明显改善,恢复了行走能力。由于结核瘤在发达国家相当罕见,除非在其他器官中证实患有结核病,否则脑内结核瘤的诊断将极其困难。即使使用MRI进行辅助检查,通常也难以提供有助于诊断的信息。然而,根据病理结果,我们患者MRI显示的结核瘤外部的环形外观以及环内侧的低强度区域似乎代表慢性肉芽肿性炎症,为排除脑转移瘤的怀疑提供了线索。要正确诊断脑内结核瘤,必须进行多学科综合考虑。

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