HIV感染患者脑脊液与颅内体积比的测量：CLASS图像分析技术
Cerebrospinal fluid-intracranial volume ratio measurements in patients with HIV infection: CLASS image analysis technique.
作者信息
Paley M N, Chong W K, Wilkinson I D, Shepherd J K, Clews A M, Sweeney B J, Hall-Craggs M A, Kendall B E, Newman S P, Harrison M J
机构信息
Department of Neurology, University College London Medical School and Middlesex Hospital, England.
出版信息
Radiology. 1994 Mar;190(3):879-86. doi: 10.1148/radiology.190.3.8115644.
PURPOSE
To prospectively study the cerebrospinal fluid volume-total intracranial volume ratio (CSF/ICV) in human immunodeficiency virus (HIV)-infected patients at various stages of disease.
MATERIALS AND METHODS
A total of 258 volume measurements were obtained with use of a 1.5-T magnetic resonance (MR) imager and the cluster localized automated spherical segmentation technique (which reduces two-dimensional pixel data from dual spin-echo MR images to a one-dimensional histogram) in 69 control subjects and 189 HIV-infected patients.
RESULTS
The CSF/ICV was statistically significantly increased in patients with late-stage (Centers for Disease Control and Prevention group IV) acquired immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation]) compared with seronegative control subjects (0.12 +/- 0.03) and patients without symptoms (0.13 +/- 0.03).
CONCLUSION
No substantial change in CSF/ICV occurs until development of late-stage AIDS.
目的
前瞻性研究处于疾病不同阶段的人类免疫缺陷病毒（HIV）感染患者的脑脊液体积与总颅内体积之比（CSF/ICV）。
材料与方法
使用1.5-T磁共振（MR）成像仪和簇定位自动球形分割技术（该技术将双自旋回波MR图像的二维像素数据简化为一维直方图），对69名对照受试者和189名HIV感染患者进行了总共258次体积测量。
结果
与血清阴性对照受试者（0.12±0.03）和无症状患者（0.13±0.03）相比，晚期（疾病控制和预防中心IV组）获得性免疫缺陷综合征（AIDS）患者的CSF/ICV在统计学上显著增加（0.16±0.05[标准差]）。
结论
在晚期AIDS出现之前，CSF/ICV无实质性变化。
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