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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nishikawa T, Tsuda A, Tanaka M, Nishikawa M, Koga I, Uchida Y

Department of Pharmacology, Kurume University School of Medicine, Japan.

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jan;18(1):149-53. doi: 10.1016/0278-5846(94)90031-0.

The present study was performed to examine the effect of naloxone on drinking behavior in three schizophrenic inpatients with psychosis, intermittent hyponatremia, and polydipsia. 2. Their body weight were checked five times daily and the maximum weight gain during a day was chosen as an index of their polydipsia. 3. After control recording for six weeks, a daily naloxone (0.6 mg) injection series was performed once every two weeks for three series (six weeks). Withdrawal of this drug for six weeks resulted in weight gain recovering to control level. 4. The present study showed that naloxone seems to be a potential treatment for psychiatric patients displaying self-induced water intoxication and that endogenous opioid systems are involved in the compulsive drinking behavior of this syndrome.

本研究旨在检测纳洛酮对三名患有精神病、间歇性低钠血症和烦渴的精神分裂症住院患者饮水行为的影响。2. 每天对他们的体重检查五次，选取一天中的最大体重增加量作为他们烦渴程度的指标。3. 在进行六周的对照记录后，每两周进行一次每日注射纳洛酮（0.6毫克）的系列操作，共进行三个系列（六周）。停用该药物六周后体重增加恢复到对照水平。4. 本研究表明，纳洛酮似乎是治疗表现出自发性水中毒的精神疾病患者的一种潜在疗法，并且内源性阿片系统参与了该综合征的强迫性饮水行为。

Nishikawa T, Tsuda A, Tanaka M, Nishikawa M, Koga I, Uchida Y

Department of Pharmacology, Kurume University School of Medicine, Japan.

Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jan;18(1):149-53. doi: 10.1016/0278-5846(94)90031-0.

The present study was performed to examine the effect of naloxone on drinking behavior in three schizophrenic inpatients with psychosis, intermittent hyponatremia, and polydipsia. 2. Their body weight were checked five times daily and the maximum weight gain during a day was chosen as an index of their polydipsia. 3. After control recording for six weeks, a daily naloxone (0.6 mg) injection series was performed once every two weeks for three series (six weeks). Withdrawal of this drug for six weeks resulted in weight gain recovering to control level. 4. The present study showed that naloxone seems to be a potential treatment for psychiatric patients displaying self-induced water intoxication and that endogenous opioid systems are involved in the compulsive drinking behavior of this syndrome.

本研究旨在检测纳洛酮对三名患有精神病、间歇性低钠血症和烦渴的精神分裂症住院患者饮水行为的影响。2. 每天对他们的体重检查五次，选取一天中的最大体重增加量作为他们烦渴程度的指标。3. 在进行六周的对照记录后，每两周进行一次每日注射纳洛酮（0.6毫克）的系列操作，共进行三个系列（六周）。停用该药物六周后体重增加恢复到对照水平。4. 本研究表明，纳洛酮似乎是治疗表现出自发性水中毒的精神疾病患者的一种潜在疗法，并且内源性阿片系统参与了该综合征的强迫性饮水行为。