Ganz J C, Backlund E O, Thorsen F A
Department of Neurosurgery, Haukeland Hospital, Bergen, Norway.
Stereotact Funct Neurosurg. 1993;61 Suppl 1:30-7. doi: 10.1159/000100657.
Fifteen patients were treated in the Gamma Knife Unit and followed for 18 months or longer. Four patients had Cushing's disease, 4 had acromegaly, 3 had Nelson's syndrome and 3 had prolactinomas. One patient had no endocrinopathy. One of the patients with acromegaly and 2 of those with prolactinomas had been operated prior to Gamma Knife treatment. Radiological tumor localization was not an insuperable problem in this series. The effect of Gamma Knife treatment on the anterior pituitary neoplasia, as such, was consistently successful. All the tumors which received 10 Gy or more to the edge showed either a reduction in volume or at least cessation of growth. On the other hand, the effect of the treatment was less consistent in respect to the endocrinopathies. These results are discussed in respect of dose and tumor size. It is suggested that the role of the Gamma Knife in the treatment of pituitary adenomas requires further clarification, based on prospective studies.
15例患者在伽玛刀治疗中心接受治疗，并随访18个月或更长时间。4例患有库欣病，4例患有肢端肥大症，3例患有尼尔森综合征，3例患有催乳素瘤。1例患者无内分泌疾病。1例肢端肥大症患者和2例催乳素瘤患者在伽玛刀治疗前曾接受过手术。在本系列中，放射学肿瘤定位并非不可克服的问题。伽玛刀治疗垂体前叶肿瘤本身一直是成功的。所有边缘接受10 Gy或更高剂量照射的肿瘤均显示体积缩小或至少停止生长。另一方面，治疗对内分泌疾病的效果不太一致。根据剂量和肿瘤大小对这些结果进行了讨论。基于前瞻性研究，建议伽玛刀在垂体腺瘤治疗中的作用需要进一步阐明。
