McGiff J C, Quilley C P, Carroll M A
Department of Pharmacology, New York Medical College, Valhalla 10595.
Steroids. 1993 Dec;58(12):573-9. doi: 10.1016/0039-128x(93)90098-8.
Arachidonic acid can be metabolized to diverse products which differ widely in their biological activities. These metabolites affect basic biological mechanisms such as vascular reactivity and transport function in critical nephron segments. Metabolism of arachidonic acid is discretely localized to specific cells and differs within segments of the nephron; for example, cells of the medullary ascending limb of Henle's loop have a considerable capacity to generate cytochrome P450-dependent arachidonate metabolites but have negligible cyclooxygenase activity. Arachidonic acid metabolites participate in fluid and electrolyte homeostasis, and in the regulation of tissue blood flow, and act as modulators of vasoactive hormones, and, thereby, make important contributions to integrated renal function.
花生四烯酸可代谢为多种生物活性差异很大的产物。这些代谢产物影响基本的生物学机制，如关键肾单位节段的血管反应性和转运功能。花生四烯酸的代谢离散地定位于特定细胞，且在肾单位各节段有所不同；例如，亨氏袢髓质升支的细胞具有相当强的生成细胞色素P450依赖性花生四烯酸代谢产物的能力，但环氧化酶活性可忽略不计。花生四烯酸代谢产物参与体液和电解质平衡以及组织血流的调节，并作为血管活性激素的调节剂，从而对肾脏的整体功能做出重要贡献。
