Sand N P, Juelsgaard P
Kardiologisk afdeling, Skejby Sygehus, Arhus.
Ugeskr Laeger. 1994 Feb 21;156(8):1131-2, 1135-6.
Over a seven year period, 8.6% of 990 patients subjected to coronary arteriography because of angina pectoris were found to have normal coronary arteries (NCA). The subsequent histories of these patients were compared to those of a group of patients (N = 112) with coronary atherosclerosis (CAD). On average 44 months after coronary arteriography, 2.4% (NCA) had died versus 20.5% (CAD) (p < 0.001). Myocardial infarction had occurred in 0% (NCA) versus 12.8% (CAD) of the survivors (p < 0.001). Chest pain was unchanged or had worsened in 58.2% (NCA) versus 21.1% (CAD) (p < 0.001). Of the NCA patients, 33.3% had ischaemia during exercise-ECG. Three patients developed ischaemia during hyperventilation test. Eighty % (NCA) versus 63.9% (CAD) gave up work due to chest pain (p < 0.05). Further, 55.7% (NCA) versus 34.6% (CAD) had reduced daily activities (p < 0.01); similarly, the frequency of divorce was higher in the NCA group (10.2%) than in the CAD group (1.3%) (p < 0.05).
在七年时间里，因心绞痛接受冠状动脉造影的990例患者中，8.6%被发现冠状动脉正常（NCA）。将这些患者的后续病史与一组冠状动脉粥样硬化（CAD）患者（N = 112）的病史进行比较。冠状动脉造影平均44个月后，NCA组有2.4%的患者死亡，而CAD组为20.5%（p < 0.001）。幸存者中，NCA组心肌梗死发生率为0%，而CAD组为12.8%（p < 0.001）。NCA组58.2%的患者胸痛未缓解或加重，而CAD组为21.1%（p < 0.001）。NCA组患者中，33.3%在运动心电图检查时有缺血表现。3例患者在过度通气试验中出现缺血。因胸痛放弃工作的NCA组患者占80%，而CAD组为63.9%（p < 0.05）。此外，NCA组55.7%的患者日常活动减少，而CAD组为34.6%（p < 0.01）；同样，NCA组的离婚率（10.2%）高于CAD组（1.3%）（p < 0.05）。
