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[胃十二指肠溃疡、胃癌和结肠癌患者静脉外周血及病变引流血液中T和B淋巴细胞亚群]

[Subpopulations of T and B lymphocytes in venous peripheral blood and blood draining from lesions in patients with gastroduodenal ulcer, and gastric and colonic cancer].

作者信息

Rachel F, Rogozińska-Myśliwiec A

机构信息

Oddziału Chirurgicznego Szpitala Rejonowego, Gorlicach.

出版信息

Wiad Lek. 1993 Jun;46(11-12):433-40.

PMID:8116293
Abstract

In 30 patients with gastric and colonic cancer and 30 patients with gastroduodenal ulcer treated in a surgery department the absolute number and per cent of leucocytes, number of lymphocytes, active T-rosettes, B-cells, T-cells, populations of helper T-cells, suppressor T-cells, and T4/T8 ratio were determined in peripheral venous blood and venous blood draining the lesion. On the basis of these studies it was found that in patients with gastroduodenal ulcer and gastric and colonic cancer a decrease occurs of the number of immunocompetent cells, particularly of T-cells and helper T-cells. In patients with cancer a decrease was observed in the region of tumour particularly of the size of helper B and T-cells populations.

摘要

在某外科治疗的30例胃癌和结肠癌患者以及30例胃十二指肠溃疡患者中,测定了外周静脉血和病变引流静脉血中的白细胞绝对数和百分比、淋巴细胞数、活性T花环、B细胞、T细胞、辅助性T细胞群、抑制性T细胞群以及T4/T8比值。基于这些研究发现,胃十二指肠溃疡患者以及胃癌和结肠癌患者体内免疫活性细胞数量减少,尤其是T细胞和辅助性T细胞。在癌症患者中,肿瘤区域的细胞数量减少,尤其是辅助性B细胞和T细胞群的数量。

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