Wang T W, Byrne C D, Hales C N
Department of Clinical Biochemistry, Addenbrookes Hospital, Cambridge, UK.
Biochim Biophys Acta. 1994 Mar 3;1211(2):234-8. doi: 10.1016/0005-2760(94)90274-7.
The effect of ethanol on hepatic lipoprotein secretion is not fully understood. This study shows that exposure of HepG2 cells to ethanol significantly increases intracellular apolipoprotein B, apo B mRNA and secreted apolipoprotein B. No other agent has been shown to produce such an increase in apolipoprotein B synthesis or apolipoprotein B mRNA levels.
乙醇对肝脏脂蛋白分泌的影响尚未完全明确。本研究表明，将HepG2细胞暴露于乙醇中会显著增加细胞内载脂蛋白B、载脂蛋白B信使核糖核酸以及分泌型载脂蛋白B的含量。尚无其他因素被证实可使载脂蛋白B合成或载脂蛋白B信使核糖核酸水平出现如此程度的升高。
