Maier W, Minges J, Lichtermann D
Psychiatrische Klinik, Universität Mainz, Germany.
Eur Arch Psychiatry Clin Neurosci. 1993;243(3-4):205-11. doi: 10.1007/BF02190729.
The co-occurrence of alcoholism and anxiety disorders in epidemiological and clinical samples is well established. Self-medication of anxiety disorder probands with the anxiolytic substance alcohol might be one reason for this association. Common susceptibility factors of both disorders might be alternative explanations. Controlled family studies recruiting probands with panic disorder and alcoholism are powerful tools to answer this question. A family study of this kind, however, is not available. The present study investigated 113 families of probands with either panic disorder or alcoholism or both (but without affective or psychotic disorders) and 80 families of healthy controls in order to estimate the degree of co-occurrence of the two disorders in non-treated samples of relatives and to explore the magnitude of overlap between susceptibility factors of the two disorders. The co-occurrence of the two disorders was relatively rare in all samples of families under study. Overlap of susceptibility factors was demonstrated by an elevated risk of alcoholism in relatives of probands with panic disorder.
酒精成瘾与焦虑症在流行病学和临床样本中的共现已得到充分证实。焦虑症先证者用抗焦虑物质酒精进行自我治疗可能是这种关联的一个原因。这两种疾病的共同易感性因素可能是其他解释。招募惊恐障碍和酒精成瘾先证者的对照家族研究是回答这个问题的有力工具。然而，目前尚无此类家族研究。本研究调查了113个患有惊恐障碍或酒精成瘾或两者皆有的先证者家庭（但无情感或精神障碍）以及80个健康对照家庭，以估计这两种疾病在未经治疗的亲属样本中的共现程度，并探讨这两种疾病易感性因素之间的重叠程度。在所研究的所有家庭样本中，这两种疾病的共现相对较少。惊恐障碍先证者亲属中酒精成瘾风险升高证明了易感性因素的重叠。
