[The cause of benign and malignant courses of infection due to different strains of Pseudomonas aeruginosa].

Two groups of rats with experimental wound infection caused by various Ps. aeruginosa strains were investigated. The development of the disease was characterized as benign in the group infected by the first strain. Infection was presented as local inflammation. As for the second strain, the infection having features of malignancy was often presented in the form of septicopyemia. It appeared that the difference between the clinical course of the two compared groups correlated with those in humoral immunity status. The animal reaction to administration of both strains was agglutinative antibody formation. Besides agglutination, antibodies formed against the first strain caused the expressed complement-dependent lysis of bacterial cells. No lysis of bacteria of the second strain was observed.