Dyr W, Krzaścik P, Kostowski W
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Pol J Pharmacol. 1993 Jul-Aug;45(4):369-79.
The effects of calcium channel inhibitors on ethanol intake and dependence in Wistar rats were studied. Nifedipine and isradipine were suspended in 1% Tween 40 saline solution and administered ip 60 min prior to testing. Audiogenic seizure response evaluation was performed after 5 days of ethanol treatment. Both nifedipine and isradipine significantly reduced the intensity score of convulsions and, in doses of 2.5 and 5.0 mg/kg, respectively, abolished them. Both drugs significantly reduced ethanol preference and intake in the high preference group of animals. Our results support the observations that certain dihydropyridine derivatives are capable of attenuating both ethanol preference and physical dependence.
研究了钙通道抑制剂对Wistar大鼠乙醇摄入和依赖性的影响。硝苯地平和伊拉地平悬浮于1%吐温40盐溶液中，在测试前60分钟腹腔注射给药。乙醇处理5天后进行听源性惊厥反应评估。硝苯地平和伊拉地平均显著降低惊厥强度评分，分别以2.5和5.0mg/kg的剂量可消除惊厥。两种药物均显著降低高偏好组动物的乙醇偏好和摄入量。我们的结果支持以下观察结果：某些二氢吡啶衍生物能够减弱乙醇偏好和身体依赖性。
