Bae S J, Sturtevant J M
Department of Chemistry, Yale University, New Haven, CT 06511.
Chem Phys Lipids. 1993 Nov;66(1-2):47-53. doi: 10.1016/0009-3084(93)90030-7.
Differential scanning calorimetry (DSC) is employed in a study of the effects of the p-nitrophenyl esters of the even numbered fatty acids from C6 (caproic acid) to C18 (stearic acid) on the main phase transition of multilamellar suspensions of dimyristoylphosphatidylcholine (DMPC). Mole fractions in the range of 0.02-0.12 were used. Within this concentration range the observed transitions could be well fit on the basis of a model assuming ideal behavior of the esters in both the gel and liquid crystal phases of the lipid, and independently additive van't Hoff and impurity broadening. As expected on the basis of this model, the transition temperatures decreased linearly with increasing ester concentration and the transition enthalpies were independent of ester concentration. Significant differences between the effects of the various esters were observed, but these did not change with changing ester chain length in any regular fashion.
差示扫描量热法（DSC）被用于研究从C6（己酸）到C18（硬脂酸）的偶数脂肪酸的对硝基苯酯对二肉豆蔻酰磷脂酰胆碱（DMPC）多层悬浮液主相变的影响。使用的摩尔分数范围为0.02 - 0.12。在此浓度范围内，基于一个假设酯在脂质的凝胶相和液晶相中均表现为理想行为以及独立加和的范特霍夫和杂质展宽的模型，所观察到的相变能够得到很好的拟合。基于该模型预期，转变温度随酯浓度增加呈线性下降，且转变焓与酯浓度无关。观察到各种酯的影响存在显著差异，但这些差异并未随着酯链长度的变化以任何规则方式改变。
