Gábor G, Jávor T, Szám I, Török E
MMW Munch Med Wochenschr. 1975 Nov 14;117(46):1853-6.
The blood pressure lowering effects of prindolol (2 x 5 mg daily) and of the combination prindolol (2 x5 mg) + clopamide (10 mg) were investigated in a single blind controlled study on 61 patients with slight hypertension and compared with placebo in another group of patients. In both groups, a significant lowering of blood pressure, both lying down and standing, could be achieved, the fall in blood pressure in standing being significantly better with the combination treatment. The number of responders was greater with the combination therapy than with prindolol alone.
在一项针对61例轻度高血压患者的单盲对照研究中,研究了吲哚洛尔(每日2次,每次5毫克)以及吲哚洛尔(2×5毫克)+氯噻酮(10毫克)联合用药的降压效果,并与另一组使用安慰剂的患者进行了比较。在两组中,无论卧位还是立位,血压均显著降低,联合治疗时立位血压下降情况明显更好。联合治疗的有效应答者数量比单独使用吲哚洛尔时更多。