Magnussen C R, Doherty J M, Hess R A, Tschudy D P
Neurology. 1975 Dec;25(12):121-5. doi: 10.1212/wnl.25.12.1121.
A 36-year-old white man had both acute intermittent porphyria and long-standing idiopathic grand mal seizures. Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria. Comparison of urinary levels of the porphyrin precursors, delta aminolevulinic acid and porphobilinogen, under controlled diet conditions before and after withdrawal of diphenylhydantoin, showed that this drug accounted for approximately one-half of the porphyrin precursor excretion. Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin. Bromides appeared to be approximately as effective as diphenylhydantoin for seizure control in this patient.
一名36岁的白人男性同时患有急性间歇性卟啉病和长期特发性癫痫大发作。苯妥英显然对急性间歇性卟啉病的临床和生化指标产生了不利影响。在控制饮食条件下，停用苯妥英前后对比尿中卟啉前体δ-氨基乙酰丙酸和胆色素原的水平，结果显示该药物约占卟啉前体排泄量的一半。停用苯妥英后，卟啉病有显著的临床改善。在该患者中，溴化物在控制癫痫发作方面似乎与苯妥英效果相当。
