Willison H J, Veitch J
University of Glasgow Department of Neurology, Southern General Hospital, Scotland, UK.
J Neuroimmunol. 1994 Mar;50(2):159-65. doi: 10.1016/0165-5728(94)90042-6.
Circulating IgG antibodies to carbohydrate determinants on GQ1b ganglioside are found in the acute phase sera of patients with Miller Fisher syndrome, a variant of Guillain-Barré syndrome. Here we report that the IgG subclass distribution of the anti-GQ1b antibodies is mainly restricted to IgG1 and IgG3 antibodies, subclasses typically associated with a T cell-dependent immune response to protein antigens. This is highly unusual in that IgG responses to carbohydrate determinants are typically of the IgG2 subclass. Anti-GQ1b antibodies also have a limited ability to bind GQ1b in a membrane-like environment, particularly at body temperature. These data suggest that the antigen initiating the immune response in MFS is not likely GQ1b but an unidentified cross-reactive glycoprotein antigen(s). Similar results were obtained for anti-GM1 IgG antibodies in Guillain-Barré syndrome.
在格林-巴利综合征的一种变异型——米勒-费雪综合征患者的急性期血清中，发现了针对GQ1b神经节苷脂上碳水化合物决定簇的循环IgG抗体。在此我们报告，抗GQ1b抗体的IgG亚类分布主要局限于IgG1和IgG3抗体，这两个亚类通常与对蛋白质抗原的T细胞依赖性免疫反应相关。这非常不寻常，因为对碳水化合物决定簇的IgG反应通常属于IgG2亚类。抗GQ1b抗体在类似膜的环境中结合GQ1b的能力也有限，尤其是在体温条件下。这些数据表明，引发米勒-费雪综合征免疫反应的抗原不太可能是GQ1b，而是一种未确定的交叉反应性糖蛋白抗原。在格林-巴利综合征中，抗GM1 IgG抗体也获得了类似结果。
