人死后脑组织中反应性小胶质细胞对MRP14、27E10、α干扰素和白细胞共同抗原的表达

Expression of MRP14, 27E10, interferon-alpha and leukocyte common antigen by reactive microglia in postmortem human brain tissue.

作者信息

Akiyama H, Ikeda K, Katoh M, McGeer E G, McGeer P L

机构信息

Tokyo Institute of Psychiatry, Japan.

出版信息

J Neuroimmunol. 1994 Mar;50(2):195-201. doi: 10.1016/0165-5728(94)90046-9.

DOI:10.1016/0165-5728(94)90046-9

PMID:8120141

Abstract

We have immunohistochemically investigated the localization of a panel of leukocyte-related molecules in postmortem human brain tissue from control subjects and patients with Alzheimer's disease (AD). Microglia constitutively express leukocyte common antigens (LCA) with CD45RB determinants. Depending on the state of activation, microglia become positive for the myeloid cell-specific calcium binding protein MRP14, LCA with CD45RO determinant, interferon-alpha, and an antigen recognized by monoclonal antibody 27E10. In AD lesions, these cells are activated in a manner consistent with a chronic inflammatory state. The results of this study have shown further parallels in protein expression between activated microglia and activated leukocytes of the myeloid lineage.

摘要

我们通过免疫组织化学方法研究了一组白细胞相关分子在对照组和阿尔茨海默病（AD）患者死后人类脑组织中的定位。小胶质细胞组成性表达带有CD45RB决定簇的白细胞共同抗原（LCA）。根据激活状态，小胶质细胞对髓样细胞特异性钙结合蛋白MRP14、带有CD45RO决定簇的LCA、干扰素-α以及单克隆抗体27E10识别的一种抗原呈阳性。在AD病变中，这些细胞以与慢性炎症状态一致的方式被激活。这项研究的结果进一步显示了激活的小胶质细胞与髓系谱系激活的白细胞在蛋白质表达上的相似性。