Malaviya R, Ross E A, MacGregor J I, Ikeda T, Little J R, Jakschik B A, Abraham S N
Department of Pathology, Washington University School of Medicine, St. Louis, MO.
J Immunol. 1994 Feb 15;152(4):1907-14.
Most studies of mast cells have been directed at their role in the pathophysiology of IgE-mediated allergic reactions with little recognition of their participation in bacterial infections. We report that mast cells can specifically bind FimH, a mannose-binding subunit on type 1 fimbriae expressed by Escherichia coli and other enterobacteria. This interaction triggers mast cell phagocytosis and killing of the bacteria within vacuoles and through the release of superoxide anions. Also, in view of the fact that mast cells have the capacity to release inflammatory mediators and are particularly abundant in the skin, mucosal surfaces, and around blood vessels, we suggest that these cells play an important role in host defense against microbial infection.
大多数关于肥大细胞的研究都聚焦于它们在IgE介导的过敏反应病理生理学中的作用，而很少认识到它们参与细菌感染。我们报告称，肥大细胞能特异性结合FimH，FimH是大肠杆菌和其他肠道细菌表达的1型菌毛上的一种甘露糖结合亚基。这种相互作用触发肥大细胞的吞噬作用，并在液泡内以及通过释放超氧阴离子杀死细菌。此外，鉴于肥大细胞有释放炎症介质的能力，且在皮肤、黏膜表面和血管周围特别丰富，我们认为这些细胞在宿主抵御微生物感染中发挥重要作用。
