Higo K, Karasawa A
Department of Pharmacology, Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Jpn J Pharmacol. 1993 Dec;63(4):521-3. doi: 10.1254/jjp.63.521.
The antithrombotic effects of the thromboxane (TX) A2-receptor antagonist and aspirin were determined using a photochemically-induced arterial thrombosis model in the femoral arteries of guinea pigs. KW-3635 (sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)ethylidene]-6,11- dihydrodibenz[b,e]-oxepine-2-carboxylate monohydrate) and BM-13505, both of which are TXA2-receptor antagonists, and aspirin inhibited the thrombus formation at the doses that inhibited the ex vivo platelet aggregation induced by sodium arachidonate (100 microM) or collagen (3 micrograms/ml). These results support the notion that TXA2 is an important mediator in the present model of arterial thrombogenesis.
利用光化学诱导的豚鼠股动脉血栓形成模型，测定了血栓素（TX）A2受体拮抗剂和阿司匹林的抗血栓作用。KW-3635（（E）-11-[2-（5,6-二甲基-1-苯并咪唑基）亚乙基]-6,11-二氢二苯并[b,e] -氧杂环庚英-2-羧酸钠一水合物）和BM-13505这两种TXA2受体拮抗剂，以及阿司匹林，在抑制花生四烯酸钠（100 microM）或胶原（3微克/毫升）诱导的体外血小板聚集的剂量下，均能抑制血栓形成。这些结果支持了TXA2在目前的动脉血栓形成模型中是重要介质这一观点。
