Sabesin S M, Kuiken L B, Ragland J B
Science. 1975 Dec 26;190(4221):1302-4. doi: 10.1126/science.812181.
Abnormal lipoproteins and drcreased lecithin: cholesterol acyltransferase activity are found in rat plasma following intraperitoneal injection of D-galactosamine. The changes observed, including absence of alpha-lipoprotein and the presence of lipoproteins rich in phospholipid and unesterified cholesterol but deficient in cholesteryl esters, are remarkably similar to changes found in human pathologic states of lecithin: cholesterol acyltransferase deficiency. When examined by electron microscopy, all of the major lipoprotein classes isolated by ultracentrifugation showed morphological abnormalities including the formation of rouleaus consisting of disk-shaped particles.
