Potts W K, Wakeland E K
Center for Mammalian Genetics, University of Florida, Gainesville 32610-0275.
Trends Genet. 1993 Dec;9(12):408-12. doi: 10.1016/0168-9525(93)90103-o.
Evidence from the house mouse (Mus) suggests that the extreme diversity of genes of the major histocompatibility complex (MHC) results from three different forms of selection involving infectious disease (pestilence), inbreeding (incest) and MHC-based mating (sexual) preferences. MHC-based disassortative mating preferences are presumed to have evolved because they reduce homozygosity throughout the genome, and particularly within loci linked to the MHC. Progeny derived from such disassortative matings would enjoy increased fitness because of both reduced levels of inbreeding depression and increased resistance to infectious disease arising from their increased MHC heterozygosity.
小家鼠（Mus）的证据表明，主要组织相容性复合体（MHC）基因的极端多样性源于三种不同形式的选择，包括传染病（瘟疫）、近亲繁殖（乱伦）和基于MHC的交配（性）偏好。基于MHC的异交偏好被认为已经进化，因为它们降低了整个基因组的纯合性，特别是与MHC相关的基因座内的纯合性。源于这种异交的后代将由于近亲繁殖衰退水平的降低以及由于MHC杂合性增加而产生的对传染病抵抗力的增强而享有更高的适应性。
