Zenkov N K, Dushkin M I, Liubimov G Iu, Men'shchikova E B
Vopr Med Khim. 1994 Jan-Feb;40(1):2-4.
Oxidative metabolism of murine peritoneal macrophages was studied after cultivation in a mixture containing acetylated low density lipoproteins within 24 and 48 hr using luminol- and lucigenin-dependent chemiluminescence. Chemiluminescence of foamy cells, induced by opsonized zymosan, was not distinctly altered as compared with native macrophages; at the same time, the rate of both lucigenin- and luminol-dependent spontaneous chemiluminescence was distinctly decreased. The imbalance of the oxidative reactions observed enables the authors to propose the antioxidative mechanism of atherosclerotic lesion.
利用鲁米诺和光泽精依赖的化学发光法，研究了在含有乙酰化低密度脂蛋白的混合物中培养24小时和48小时后小鼠腹腔巨噬细胞的氧化代谢。与天然巨噬细胞相比，经调理酵母聚糖诱导的泡沫细胞的化学发光没有明显改变；同时，光泽精和鲁米诺依赖的自发化学发光速率明显降低。观察到的氧化反应失衡使作者能够提出动脉粥样硬化病变的抗氧化机制。
