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[尿激酶抑制剂对人尿液有效纤溶活性的影响]

[The effect of urokinase inhibitors on effective fibrinolytic activity of human urine].

作者信息

Potapenko V E, Shataeva L K

出版信息

Vopr Med Khim. 1994 Jan-Feb;40(1):37-8.

PMID:8122409
Abstract

The levels of fibrinolytic activity of human urine as a source of the thrombolytic enzyme urokinase in various volunteers differing in sex and age. The fibrinolytic activity was distinctly altered after mixing of urine obtained from various donor groups as a result of varying quantitative and qualitative contents of urokinase inhibitors in individual volunteers. The specific biological activity of urokinase was studied in the presence of various inhibitors. Prescreening of the initial raw material (urine) should be made to isolate the most effective samples of the thrombolytic enzyme urokinase.

摘要

作为溶栓酶尿激酶来源的人尿在不同性别和年龄的志愿者中的纤溶活性水平。由于个体志愿者中尿激酶抑制剂的定量和定性含量不同,将来自不同供体组的尿液混合后,纤溶活性发生了明显变化。在各种抑制剂存在的情况下研究了尿激酶的比生物活性。应对初始原料(尿液)进行预筛选,以分离出溶栓酶尿激酶最有效的样本。

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