[螺-α-亚甲基-γ-丁内酯的杀螺活性]
[Molluscacidal activity of spiro-alpha-methylene-gamma-butyrolactone].
作者信息
Rücker G, Hostettmann K, Gajewski W, Löbbert M, Böken P
机构信息
Pharmazeutisches Institut, Rheinischen Friedrich-Wilhelms-Universität Bonn.
出版信息
Arch Pharm (Weinheim). 1993 Dec;326(12):941-5. doi: 10.1002/ardp.19933261205.
PMID:8122964
Abstract
The alpha-methylene-gamma-butyrolactones 1-28 were tested in vitro for molluscicidal activity against Biomphalaria glabrata. The racemic compound 25 shows the best activity. The synthesis was carried out by modified Reformatzky reaction of the corresponding carbonyl compounds and bromomethylacrylic acid ethyl ester. 7-10, 17 and 22-27 have been synthesized for the first time.
摘要
对α-亚甲基-γ-丁内酯1-28进行了体外抗光滑双脐螺杀螺活性测试。外消旋化合物25表现出最佳活性。通过相应羰基化合物与溴甲基丙烯酸乙酯的改良Reformatzky反应进行合成。7-10、17以及22-27为首次合成。
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