DNA topoisomerases from Streptomyces noursei: influence of coumarins and quinolones on the enzymic activity.
作者信息
Störl K, Störl J, Roth M, Zimmer C
机构信息
Department of Molecular Biology, University of Jena, Germany.
出版信息
Biochim Biophys Acta. 1994 Mar 2;1199(2):143-8. doi: 10.1016/0304-4165(94)90109-0.
PMID:8123663
Abstract
DNA topoisomerases have been purified from Streptomyces noursei. DNA gyrase and topoisomerase I show a differential sensitivity against quinolones and coumarins compared to the E. coli enzymes. Streptomyces gyrase is resistant to much higher levels of various drugs than is the E. coli enzyme. The observed differences between the gyrases from streptomycetes and E. coli are discussed in the light of present literature data.
摘要
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