药物及相关物质中杂质概况的评估。第11部分——色谱法和光谱法在药物合成中副反应评估中的作用。
Estimation of impurity profiles in drugs and related materials. Part 11--The role of chromatographic and spectroscopic methods in the estimation of side-reactions in drug syntheses.
作者信息
Görög S, Balogh G, Csehi A, Csizér E, Gazdag M, Halmos Z, Hegedüs B, Herényi B, Horváth P, Laukó A
机构信息
Chemical Works of G. Richter Ltd., Budapest, Hungary.
出版信息
J Pharm Biomed Anal. 1993 Nov-Dec;11(11-12):1219-26. doi: 10.1016/0731-7085(93)80107-c.
Impurities in drugs are classified on the basis of the types of side-reactions in drug syntheses resulting in their formation. This is shown by summarizing the authors' earlier results in the field of impurity profiling of 19-nor-steroids, ethynodiol diacetate, mazipredone, pipecuronium bromide, flumecinol, enalapril, pyridinol carbamate, phenylbutazone, thymotrinan and some new results related to danazol and famotidine.
药物中的杂质根据药物合成中导致其形成的副反应类型进行分类。这通过总结作者早期在19-去甲甾体、炔诺二醇二乙酸酯、马齐泼酮、哌库溴铵、氟美西诺、依那普利、吡啶醇氨基甲酸酯、保泰松、胸腺三肽领域的杂质分析结果以及与达那唑和法莫替丁相关的一些新结果得以体现。
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