Samaan N A, Bakdash M M, Caderao J B, Cangir A, Jesse R H, Ballantyne A J
Ann Intern Med. 1975 Dec;83(6):771-7. doi: 10.7326/0003-4819-83-6-771.
Endocrine complications after radiotherapy for tumors of the head and neck are thought to be relatively rare. The availability of synthetic hypothalamic hormones for clinical investigations and the radioimmunoassay of hormones have enabled us to study function of the hypothalamic pituitary axis in 15 patients who had radiotherapy for nasopharyngeal cancer. Fourteen had evidence of endocrine deficiency. Twelve patients had evidence of hypothalamic dysfunction, 7 developed primary pituitary hormone deficiencies, and 3 developed primary hypothyroidism. These results indicate that [1] secondary hypopituitarism due to a hypothalamic lesion after radiotherapy for nasopharyngeal cancer may be more common than suspected in the past; [2] primary hypopituitarism after irradiation of extracranial tumors can occur; and [3[ primary hypothyroidism may result from irradiation of regional neck nodes.
头颈部肿瘤放疗后的内分泌并发症被认为相对少见。用于临床研究的合成下丘脑激素的可获得性以及激素的放射免疫测定，使我们能够对15例接受鼻咽癌放疗的患者的下丘脑 - 垂体轴功能进行研究。14例有内分泌功能减退的证据。12例有下丘脑功能障碍的证据，7例出现原发性垂体激素缺乏，3例出现原发性甲状腺功能减退。这些结果表明：[1]鼻咽癌放疗后因下丘脑病变导致的继发性垂体功能减退可能比过去认为的更常见；[2]颅外肿瘤放疗后可发生原发性垂体功能减退；[3]颈部区域淋巴结放疗可能导致原发性甲状腺功能减退。
