Abel R M, Fischer J E, Buckley M J, Barnett G O, Austen W G
Arch Surg. 1976 Jan;111(1):45-50. doi: 10.1001/archsurg.1976.01360190047008.
A randomized evaluation of 44 malnourished patients, wherein 24 were used as controls and 20 received immediate postoperative parenteral hyperalimentation, indicated that five days of nutritional therapy had no notable effect on the morbidity and mortality experienced by the malnourished patients, in comparison to a third, nonmalnourished group of similar patients. Although central venous nutrition was safely administered without complications immediately after cardiac operations, clinical efficacy of this therapy could not be demonstrated. The inability to establish a dose-response relationship, and hence administer the "optimum" amount of nutrients, may have accounted for the negative results reported. Although preoperative malnutrition is associated with a poorer result after cardiac surgery, postoperative repletion of nutrients appears to be ineffective in reversing this relationship.
一项针对44名营养不良患者的随机评估，其中24名作为对照组，20名在术后立即接受肠外高营养治疗，结果表明，与第三组营养状况正常的类似患者相比，为期五天的营养治疗对营养不良患者的发病率和死亡率没有显著影响。尽管心脏手术后可安全地进行中心静脉营养且无并发症，但该治疗的临床疗效未能得到证实。无法建立剂量反应关系，从而无法给予“最佳”营养量，可能是报告结果为阴性的原因。尽管术前营养不良与心脏手术后较差的结果相关，但术后补充营养似乎无法扭转这种关系。
